The ingredients in Lupura have been clinically studied and documented extensively in their effect on Systemic Lupus Erythematosus and other Autoimmune conditions.  Lupura effectively blocks the ion channels in negative T cells and inhibit the replication of B cells which lead to the inflammatory responses that cause Lupus.

 

The efficacy of Lupura is a result of the effects of the ingredients in the formula on certain cellular ion channels.  It has previously been shown that abnormal potassium channel expression in certain autoimmune diseases is related to the abnormal immune response. (Chandy and Cahalan published in 1990 by the University of California at Irvine and “Autoimmune diseases linked to abnormal K+ channel expression in double-negative CD4−CD8−T cells,” Eur J. Immunol, Cahalan M D, Chandy G K, Grissmer S., 1990, 20: 747-751). It was shown rats with experimental SLE (Systemic Lupus Erythematosus), Diabetes (Type I) and EAE (Experimental Autoimmune Encephalitis) were tested for the Kv1.3 channel, and it was shown found that all three have the CD4 and CD8—T-Cells (double negative T-Cells) expression that inflames the various tissues associated with the respective diseases. All of these diseases show a control of lymphocyte proliferation by the Kv1.3 channel. It has independently been demonstrated that the ingredients which can be found in Lupura, are very effective at modulating the conduction by this potassium channel.


The ingredients in Lupura have been clinically proven to:


-Control inflammation through by blocking the ion channels


-Deactivate white blood cells by the changes in ion channels so that inflammatory attacks on the joints are decreased. 


-Regulate the immune system (as mediated by white blood cells) which results in lowered production of autoantibodies. 



Lupura is able to effectively block ion channels in certain lymphocytes, specifically CD4 double negative and CD8 double negative T Cells. Blocking these ion channels prevents the chain of events leading to inflammatory responses seen in autoimmune conditions.

 

Below are the clinical studies and research referenced from the US National Library of Medicine:

 

Quercetin, Resveratrol, and Curcumin are shown to reduce the severity of autoimmune symptoms and Quercetin and Curcumin reduce immunosuppressive-drug side effects.

Study published from the US National Library of Medicine Institutes of Health

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1856830/

Quercetin is shown to inhibit inflammatory responses in human blood cells.  

Study published from the US National Library of Medicine Institutes of Health

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC353125/

 

Quercetin is shown to help inhibit immunocomplex formation in patients with systemic lupus erythematosus (SLE).

Study published from the US National Library of Medicine Institutes of Health

http://www.ncbi.nlm.nih.gov/pubmed/?term=quercetin+lupus

 

Quercetin is shown to protect cartilage from Inflammation-Induced Degradation.

Study published from the US National Library of Medicine Institutes of Health

http://www.ncbi.nlm.nih.gov/pubmed/26046639

 

Quercetin is shown to reduce survival and proliferation of B-1 cells in vitro for autoimmune conditions.

Study published from the US National Library of Medicine Institutes of Health

http://www.ncbi.nlm.nih.gov/pubmed/25245014

 

Quercetin is shown to be a potent antioxidant and anti-inflammatory compound that inhibits mast cell cytokine release occurring in inflammatory and autoimmune diseases.

Study published from the US National Library of Medicine Institutes of Health

http://www.ncbi.nlm.nih.gov/pubmed/22470478

 

Quercetin is shown to alleviate block IL-12 signaling and Th1 differentiation suggesting its use in the treatment of Th1 cell-mediated autoimmune diseases.

Study published from the US National Library of Medicine Institutes of Health

http://www.ncbi.nlm.nih.gov/pubmed/15359113

 

Quercetin is shown to alleviate autoimmune conditions in rats. 

Study published from the US National Library of Medicine Institutes of Health

http://www.ncbi.nlm.nih.gov/pubmed/21092705

 

Quercetin in arthritic rats dramatically diminishes clinical signs of arthritis and alleviates experimental autoimmune encephalomyelitis.

Study published from the US National Library of Medicine Institutes of Health

http://www.ncbi.nlm.nih.gov/pubmed/18468581

Vitamin C is shown to help to reduce cell damage in patients with systemic lupus erythematosus (SLE).

Study published from the US National Library of Medicine Institutes of Health

http://www.ncbi.nlm.nih.gov/pubmed/15693087

 

Vitamin C intake may prevent the occurrence of active Systemic Lupus Erythematosus (SLE) disease according to 4 year study on Japanese patients.

Study published from the US National Library of Medicine Institutes of Health

http://www.ncbi.nlm.nih.gov/pubmed/12672194

 

Vitamin C is shown to be effective in decreasing pathological damage in experimental autoimmune myocarditis (EAM).

Study published from the US National Library of Medicine Institutes of Health

http://www.ncbi.nlm.nih.gov/pubmed/17968290

 

Vitamin C is shown to effectively control Autoimmune disease in patients.

Study published from the US National Library of Medicine Institutes of Health

http://www.ncbi.nlm.nih.gov/pubmed/7919130

 

Resveratrol is shown to alleviate symptoms in autoimmune condition.

Study published from the US National Library of Medicine Institutes of Health

http://www.ncbi.nlm.nih.gov/pubmed/17322642

 

Resveratrol is shown to display protective effects on Mice with Lupus.

Study published from the US National Library of Medicine Institutes of Health

http://www.ncbi.nlm.nih.gov/pubmed/25501752

 

Curcumin is shown to differentially regulate CD4(+) T helper cell responses in experimental autoimmune encephalomyelitis (EAE)

Study published from the US National Library of Medicine Institutes of Health

http://www.ncbi.nlm.nih.gov/pubmed/22402368

 

Curcumin demonstrates therapeutic effect in autoimmune diabetes by its actions on key immune cells responsible for β cell death.

Study published from the US National Library of Medicine Institutes of Health

http://www.ncbi.nlm.nih.gov/pubmed/24628444

 

Curcumin reduces the effect of inflammation in rats with experimental autoimmune neuritis.

Study published from the US National Library of Medicine Institutes of Health

http://www.ncbi.nlm.nih.gov/pubmed/24482305

 

Curcumin exerts protective effect on mice with Lupus Nephritis (LN).

Study published from the US National Library of Medicine Institutes of Health

http://www.ncbi.nlm.nih.gov/pubmed/23181951